CORona Drug InTEractions database

Possible Drug Candidates for COVID-19

Navan Chauhan

Abstract

COVID-19, has been officially labeled as a pandemic by the World Health Organisation. This paper presents cloperastine and vigabatrin as two possible drug candidates for combatting the disease along with the process by which they were discovered. The paper presents the discoveries made by using a connectivity map and the docking configurations used to simulate the docking.

Source: ChemRxiv

Related molecules

Name	Synonyms	Genes
Vigabatrin
Cloperastine
3C-like protease	3CLpro, Mpro, SARS coronavirus main peptidase, 3CLpro-SARS-CoV-2	rep, ORF1a-1b

Related interactions

Target	Drug	Type	Result
3C-like protease	Cloperastine
3C-like protease	Vigabatrin

Target	Target affiliation	Drug	Type	Result
Target	Target affiliation	Drug	Type	Result

Name	Synonyms	Genes	Origin
Name	Synonyms	Genes	Origin

Name	Synonyms	PubChem	DrugBank	RCSB PDB	ATC
Name	Synonyms	PubChem	DrugBank	RCSB PDB	ATC

Title	Authors	DOI	Source	Article type	Date
Title	Authors	DOI	Source	Article type	Date

Title	Status	Phases	Start Date	Prim. Comp. Date	Comp. Date	First Post. Date
Title	Status	Phases	Start Date	Prim. Comp. Date	Comp. Date	First Post. Date

CORDITE (CORona Drug InTEractions database) collects and aggregates data from PubMed, MedRxiv, BioRxiv, ChemRxiv and PMC for SARS-CoV-2. Its main focus is set on drug interactions either addressing viral proteins or human proteins that could be used to treat COVID. It collects and provides up-to-date information on computational predictions, in vitro, as well as in vivo study data.

The information provided is for research only and we cannot guarantee the correctness of the data.

Please contact dominik.heider@uni-muenster.de for further information.

Programmable access

There is an open API for access programmatically to the database. The API will print a JSON output:

Interactions

https://cordite-api.uni-muenster.de/api.php?action=list&table=interaction

Targets

https://cordite-api.uni-muenster.de/api.php?action=list&table=target

Drugs

https://cordite-api.uni-muenster.de/api.php?action=list&table=drug

Publications

https://cordite-api.uni-muenster.de/api.php?action=list&table=publication

Clinical trials

https://cordite-api.uni-muenster.de/api.php?action=list&table=clinical_trial