CORona Drug InTEractions database
Blockers of the SARS-CoV-2 3a Channel Identified by Targeted Drug Repurposing
Prabhat Pratap Singh Tomar, Miriam Krugliak, Isaiah T. Arkin
Abstract
The etiological agent of the COVID-19 pandemic is SARS-CoV-2. As a member of the Coronaviridae, the enveloped pathogen has several membrane proteins, of which two, E and 3a, were suggested to function as ion channels. In an effort to increase our treatment options, alongside providing new research tools, we have sought to inhibit the 3a channel by targeted drug repurposing. To that end, using three bacteria-based assays, we screened a library of 2839 approved-for-human-use drugs and identified the following potential channel-blockers: Capreomycin, Pentamidine, Spectinomycin, Kasugamycin, Plerixafor, Flumatinib, Litronesib, Darapladib, Floxuridine and Fludarabine. The stage is now set for examining the activity of these compounds in detailed electrophysiological studies and their impact on the whole virus with appropriate biosafety measures.
Source: PubMed
Related molecules
Name | Synonyms | Genes |
---|---|---|
3a Ion channel | ||
Pentamidine | ||
Spectinomycin | ||
Kasugamycin | ||
Plerixafor | ||
Flumatinib | ||
Litronesib | ||
Darapladib | ||
Floxuridine | ||
Fludarabine | ||
Capreomycin | Capastat |
Related interactions
Target | Target affiliation | Drug | Type | Result |
---|---|---|---|---|
Target | Target affiliation | Drug | Type | Result |
Name | Synonyms | Genes | Origin |
---|---|---|---|
Name | Synonyms | Genes | Origin |
Name | Synonyms | PubChem | DrugBank | RCSB PDB | ATC |
---|---|---|---|---|---|
Name | Synonyms | PubChem | DrugBank | RCSB PDB | ATC |
Title | Authors | DOI | Source | Article type | Date |
---|---|---|---|---|---|
Title | Authors | DOI | Source | Article type | Date |
Title | Status | Phases | Start Date | Prim. Comp. Date | Comp. Date | First Post. Date |
---|---|---|---|---|---|---|
Title | Status | Phases | Start Date | Prim. Comp. Date | Comp. Date | First Post. Date |
CORDITE (CORona Drug InTEractions database) collects and aggregates data from PubMed, MedRxiv, BioRxiv, ChemRxiv and PMC for SARS-CoV-2. Its main focus is set on drug interactions either addressing viral proteins or human proteins that could be used to treat COVID. It collects and provides up-to-date information on computational predictions, in vitro, as well as in vivo study data.
The information provided is for research only and we cannot guarantee the correctness of the data.
Please contact dominik.heider@uni-muenster.de for further information.
Programmable access
There is an open API for access programmatically to the database. The API will print a JSON output:
- Interactions
https://cordite-api.uni-muenster.de/api.php?action=list&table=interaction
- Targets
https://cordite-api.uni-muenster.de/api.php?action=list&table=target
- Drugs
https://cordite-api.uni-muenster.de/api.php?action=list&table=drug
- Publications
https://cordite-api.uni-muenster.de/api.php?action=list&table=publication
- Clinical trials
https://cordite-api.uni-muenster.de/api.php?action=list&table=clinical_trial