CORona Drug InTEractions database

Nitozoxanide

Synonyms: Nitaxozanid, Nitaxozanide, Nitazoxanida, Nitazoxanide, Nitazoxanidum

Description:

DrugBank: Nitazoxanide belongs to the class of drugs known as thiazolides. Nitazoxanide (NTZ) is a broad-spectrum anti-infective drug that markedly modulates the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, in addition to viruses. This drug is effective in the treatment of gastrointestinal infections including Cryptosporidium parvum or Giardia lamblia in healthy subjects. It is generally well tolerated. Nitazoxanide is a first-line, standard treatment for illness caused by C. parvum or G. lamblia infection in healthy (not immunosuppressed) adults and children and may also be considered in the treatment of illnesses caused by other protozoa or helminths 2. Recently, this drug has been studied as a broad-spectrum antiviral agent due to its ability to inhibit the replication of several RNA and DNA viruses 3.

DrugBank: DB00507

Related interactions

Target	Drug	Type	Result
Unspecific	Nitozoxanide
Spike glycoprotein	Nitozoxanide
3C-like protease	Nitozoxanide
Unspecific	Nitozoxanide

Related publications

Title	Author	Type
Prioritisation of potential anti-SARS-CoV-2 drug repurposing opportunities based on ability to achieve adequate target site concentrations derived from their established human pharmacokinetics	Usman Arshad, Henry Pertinez, Helen Box, Lee Tatham, Rajith KR Rajoli, Paul Curley, Megan Neary, Joanne Sharp, Neill J Liptrott, Anthony Valentijn, Christopher David, Steve P Rannard, Paul O'Neill, Ghaith Aljayyoussi, Shaun Pennington, Stephen A Ward, David J Back, Saye H Khoo, Patrick G Bray, Giancarlo Biagini, Andrew Owen
A comprehensive review on drug repositioning against coronavirus disease 2019 (COVID19)	Maryam Rameshrad, Majid Ghafoori, Amir Hooshang Mohammadpour, Mohammad Javad Dehghan Nayeri & Hossein Hosseinzadeh
Repurposing potential of FDA‐approved and investigational drugs for COVID‐19 targeting SARS‐CoV‐2 spike and main protease and validation by machine learning algorithm	Akalesh Kumar Verma, Rohit Aggarwal
Drug repurposing of nitazoxanide: can it be an effective therapy for COVID-19?	Dina B. Mahmoud, Zayyanu Shitu, Ahmed Mostafa
The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters	L. Miorin, C. E. Mire, S. Ranjbar, A. J. Hume, J. Huang, N. A. Crossland, K. M. White, M. Laporte, T. Kehrer, V. Haridas, E. Moreno, A. Nambu, S. Jangra, A. Cupic, M. Dejosez, K. A. Abo, A. E. Tseng, R. B. Werder, R. Rathnasinghe, T. Mutetwa, I. Ramos, J. Sainz de Aja, C. Garcia de Alba Rivas, M. Schotsaert, R. B. Corley, J. V. Falvo, A. Fernandez-Sesma, C. Kim, J.-F. Rossignol, A. A. Wilson, T. Zwaka, D. N. Kotton, E. M&uumlhlberger, A. Garc&iacutea-Sastre, A. E. Goldfeld,

Target	Target affiliation	Drug	Type	Result
Target	Target affiliation	Drug	Type	Result

Name	Synonyms	Genes	Origin
Name	Synonyms	Genes	Origin

Name	Synonyms	PubChem	DrugBank	RCSB PDB	ATC
Name	Synonyms	PubChem	DrugBank	RCSB PDB	ATC

Title	Authors	DOI	Source	Article type	Date
Title	Authors	DOI	Source	Article type	Date

Title	Status	Phases	Start Date	Prim. Comp. Date	Comp. Date	First Post. Date
Title	Status	Phases	Start Date	Prim. Comp. Date	Comp. Date	First Post. Date

CORDITE (CORona Drug InTEractions database) collects and aggregates data from PubMed, MedRxiv, BioRxiv, ChemRxiv and PMC for SARS-CoV-2. Its main focus is set on drug interactions either addressing viral proteins or human proteins that could be used to treat COVID. It collects and provides up-to-date information on computational predictions, in vitro, as well as in vivo study data.

The information provided is for research only and we cannot guarantee the correctness of the data.

Please contact dominik.heider@uni-muenster.de for further information.

Programmable access

There is an open API for access programmatically to the database. The API will print a JSON output:

Interactions

https://cordite-api.uni-muenster.de/api.php?action=list&table=interaction

Targets

https://cordite-api.uni-muenster.de/api.php?action=list&table=target

Drugs

https://cordite-api.uni-muenster.de/api.php?action=list&table=drug

Publications

https://cordite-api.uni-muenster.de/api.php?action=list&table=publication

Clinical trials

https://cordite-api.uni-muenster.de/api.php?action=list&table=clinical_trial