CORona Drug InTEractions database

Potential covalent drugs targeting the main protease of the SARS-CoV-2 coronavirus.

Liu S, Zheng Q, Wang Z

Abstract

Since December 2019, the newly identified coronavirus SARS-CoV-2 has caused a massive health crisis worldwide and resulted in over 70,000 COVID-19 infections so far. Clinical drugs targeting SARS-CoV-2 are urgently needed to decrease the high fatality rate of confirmed COVID-19 patients. Traditional de novo drug discovery needs more than 10 years, so drug repurposing seems the best option currently to find potential drugs for treating COVID-19.

Source: PubMed

Related molecules

Name	Synonyms	Genes
Telcagepant
Vidupiprant
Poziotinib
Fostamatinib	tamatinib
3C-like protease	3CLpro, Mpro, SARS coronavirus main peptidase, 3CLpro-SARS-CoV-2	rep, ORF1a-1b

Related interactions

Target	Drug	Type	Result
3C-like protease	Telcagepant
3C-like protease	Vidupiprant
3C-like protease	Poziotinib
3C-like protease	Fostamatinib

Target	Target affiliation	Drug	Type	Result
Target	Target affiliation	Drug	Type	Result

Name	Synonyms	Genes	Origin
Name	Synonyms	Genes	Origin

Name	Synonyms	PubChem	DrugBank	RCSB PDB	ATC
Name	Synonyms	PubChem	DrugBank	RCSB PDB	ATC

Title	Authors	DOI	Source	Article type	Date
Title	Authors	DOI	Source	Article type	Date

Title	Status	Phases	Start Date	Prim. Comp. Date	Comp. Date	First Post. Date
Title	Status	Phases	Start Date	Prim. Comp. Date	Comp. Date	First Post. Date

CORDITE (CORona Drug InTEractions database) collects and aggregates data from PubMed, MedRxiv, BioRxiv, ChemRxiv and PMC for SARS-CoV-2. Its main focus is set on drug interactions either addressing viral proteins or human proteins that could be used to treat COVID. It collects and provides up-to-date information on computational predictions, in vitro, as well as in vivo study data.

The information provided is for research only and we cannot guarantee the correctness of the data.

Please contact dominik.heider@uni-muenster.de for further information.

Programmable access

There is an open API for access programmatically to the database. The API will print a JSON output:

Interactions

https://cordite-api.uni-muenster.de/api.php?action=list&table=interaction

Targets

https://cordite-api.uni-muenster.de/api.php?action=list&table=target

Drugs

https://cordite-api.uni-muenster.de/api.php?action=list&table=drug

Publications

https://cordite-api.uni-muenster.de/api.php?action=list&table=publication

Clinical trials

https://cordite-api.uni-muenster.de/api.php?action=list&table=clinical_trial