Ro5 Bioactivity Lab: Identification of Drug Candidates for COVID-19
Zeyu Yang, Orestis Bastas, Mikhail Demtchenko, Aurimas Pabrinkis, Cooper Stergis, Jamieson Danius, Bačkis Charles, Dazler Knuff, Žygimantas Jočys, Roy Tal
Abstract
The public health emergency known as the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a large number of deaths worldwide and major socioeconomic disruption. To date, no broadly effective antiviral treatment or vaccine has been developed for COVID-19. In response to this dire situation, Ro5 deployed its AI Lab to accelerate the search for potential treatments. This report focuses on our use of the Ro5 Bioactivity model, which has been designed to predict the inhibitory activity of small molecules against protein targets. The model screened a vast range of compounds in silico to uncover potential inhibitors of the SARS-CoV-2 3CL protease. We hereby present the most propitious candidates from this screen. The highest-ranking molecules include Nelfinavir, Saquinavir, Itacitinib, Kynostatin-272, BOG-INS-6c2-1, and BEN-VAN-d2b-11. Subsequent docking simulations corroborate their plausibility as 3CLpro inhibitors. Nelfinavir and Itacitinib hold the most promise for drug repurposing, among all the molecules proposed herein, due to their high predicted inhibition and affinity against the 3CL protease, favourable pharmacokinetics, and encouraging experimental data for treating viral replication and hyperinflammation, respectively.
CORDITE (CORona Drug InTEractions database) collects and aggregates data from PubMed, MedRxiv, BioRxiv, ChemRxiv and PMC for SARS-CoV-2. Its main focus is set on drug interactions either addressing viral proteins or human proteins that could be used to treat COVID.
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