Several FDA-approved drugs effectively inhibit SARS-CoV-2 infection in vitro
Hua-Long Xiong, Jia-Li Cao, Chen-Guang Shen, Jian Ma, Xiao_Yang Qiao, Tian_Shu Shi, Yang Yang, Sheng-Xiang Ge, Jun Zhang, Tian-Ying Zhang, Quan Yuan, Ning-Shao Xia
Abstract
To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 μM.
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